Assay Detail
Binding
CHEMBL3606140
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Inhibition of Electrophorus electricus AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate addition by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.34 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605838 | — | — | 1 | 7.52 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.30 |
| CHEMBL130880 | IPIDACRINE | 2.0 | 1 | 6.77 |
| CHEMBL3605836 | — | — | 1 | 6.58 |
| CHEMBL1616296 | — | — | 1 | 6.52 |
| CHEMBL1531257 | — | — | 1 | 6.50 |
| CHEMBL226970 | — | — | 1 | 6.16 |
| CHEMBL283841 | — | — | 1 | 6.13 |
| CHEMBL1617348 | — | — | 1 | 5.94 |
| CHEMBL1478435 | — | — | 1 | 5.14 |
| CHEMBL3605837 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605838 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL95 | TACRINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL130880 | IPIDACRINE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3605836 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1616296 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1531257 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL226970 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL283841 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL1617348 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL1478435 | — | IC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL3605837 | — | IC50 | = | 7410.0 | nM | 5.13 |