Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3606166

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MAOB
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.
Otto R, Penzis R, Gaube F, Adolph O, Föhr KJ, Warncke P, Robaa D, Appenroth D, Fleck C, Enzensperger C, Lehmann J, Winckler T.
J Med Chem (2015) 58 : 6710 -6715
PubMed 26278660 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.84 7.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3605359 1 7.29
CHEMBL3605361 1 7.22
CHEMBL3605360 1 7.18
CHEMBL3605358 1 7.01
CHEMBL972 SELEGILINE 4.0 1 6.57
CHEMBL3605366 1 6.50
CHEMBL3605357 1 6.44
CHEMBL3605367 1 6.19
CHEMBL3605368 1 6.16
CHEMBL1198953 1 6.00
CHEMBL3605354 1 5.80
CHEMBL3605363 1 5.54
CHEMBL3605356 1 5.41
CHEMBL3605369 1 5.41
CHEMBL3605362 1 5.29
CHEMBL3605353 1 5.15
CHEMBL3605370 1 5.01
CHEMBL3605355 1 4.85
CHEMBL3605365 1 4.68
CHEMBL3605364 1 4.64
CHEMBL8706 CLORGILINE 2.0 1 4.26
CHEMBL1087459 1 -
CHEMBL95 TACRINE 4.0 1 -
CHEMBL807 MEMANTINE 4.0 1 -
CHEMBL1098471 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3605359 IC50 = 51.0 nM 7.29
CHEMBL3605361 IC50 = 60.0 nM 7.22
CHEMBL3605360 IC50 = 66.0 nM 7.18
CHEMBL3605358 IC50 = 97.0 nM 7.01
CHEMBL972 SELEGILINE IC50 = 270.0 nM 6.57
CHEMBL3605366 IC50 = 320.0 nM 6.50
CHEMBL3605357 IC50 = 360.0 nM 6.44
CHEMBL3605367 IC50 = 650.0 nM 6.19
CHEMBL3605368 IC50 = 690.0 nM 6.16
CHEMBL1198953 IC50 = 1000.0 nM 6.00
CHEMBL3605354 IC50 = 1600.0 nM 5.80
CHEMBL3605363 IC50 = 2900.0 nM 5.54
CHEMBL3605356 IC50 = 3900.0 nM 5.41
CHEMBL3605369 IC50 = 3900.0 nM 5.41
CHEMBL3605362 IC50 = 5100.0 nM 5.29
CHEMBL3605353 IC50 = 7100.0 nM 5.15
CHEMBL3605370 IC50 = 9800.0 nM 5.01
CHEMBL3605355 IC50 = 14200.0 nM 4.85
CHEMBL3605365 IC50 = 20800.0 nM 4.68
CHEMBL3605364 IC50 = 23100.0 nM 4.64
CHEMBL8706 CLORGILINE IC50 = 54300.0 nM 4.26
CHEMBL1087459 IC50 > 150000.0 nM -
CHEMBL95 TACRINE IC50 - -
CHEMBL807 MEMANTINE IC50 - -
CHEMBL1098471 IC50 > 150000.0 nM -