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Assay Detail

CHEMBL3606223

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.
Prati F, Bergamini C, Molina MT, Falchi F, Cavalli A, Kaiser M, Brun R, Fato R, Bolognesi ML.
J Med Chem (2015) 58 : 6422 -6434
PubMed 26237241 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 5.49 5.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3604105 1 5.62
CHEMBL3604082 1 5.57
CHEMBL3604098 1 5.42
CHEMBL256155 1 5.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3604105 IC50 = 2420.0 nM 5.62
CHEMBL3604082 IC50 = 2700.0 nM 5.57
CHEMBL3604098 IC50 = 3830.0 nM 5.42
CHEMBL256155 IC50 = 4400.0 nM 5.36