Assay Detail
Functional
CHEMBL3606386
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Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation/survival after 72 hrs by resazurin dye reduction assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent 17β-Hydroxywithanolides for Castration-Resistant Prostate Cancer by High-Throughput Screening of a Natural Products Library for Androgen-Induced Gene Expression Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.29 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605565 | — | — | 1 | 7.05 |
| CHEMBL3605564 | — | — | 1 | 6.89 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.60 |
| CHEMBL517080 | WITHAFERIN A | 1.0 | 1 | 6.39 |
| CHEMBL3605566 | — | — | 1 | 5.92 |
| CHEMBL3605562 | — | — | 1 | 5.70 |
| CHEMBL3605560 | — | — | 1 | 5.51 |
| CHEMBL3605561 | — | — | 1 | - |
| CHEMBL3605563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605565 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3605564 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL517080 | WITHAFERIN A | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3605566 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3605562 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3605560 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3605561 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3605563 | — | IC50 | > | 5000.0 | nM | - |