Assay Detail
Binding
CHEMBL3606410
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cSrc T338M/S345C mutant (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.18 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604937 | — | — | 1 | 7.77 |
| CHEMBL3604921 | — | — | 1 | 7.55 |
| CHEMBL1232944 | — | — | 1 | 7.37 |
| CHEMBL3604910 | — | — | 1 | 7.32 |
| CHEMBL3604938 | — | — | 1 | 6.58 |
| CHEMBL3604924 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604937 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3604921 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1232944 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3604910 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3604938 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3604924 | — | IC50 | = | 349.0 | nM | 6.46 |