Assay Detail
Binding
CHEMBL3606693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-flagged recombinant HDAC1 (unknown origin) pre-incubated for 1 hr before substrate addition by homogeneous fluorogenic HDAC assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.66 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605502 | — | — | 1 | 7.12 |
| CHEMBL3605507 | — | — | 1 | 7.11 |
| CHEMBL3605506 | — | — | 1 | 7.10 |
| CHEMBL3605495 | — | — | 1 | 7.09 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 7.01 |
| CHEMBL3605508 | — | — | 1 | 6.89 |
| CHEMBL3605496 | — | — | 1 | 6.72 |
| CHEMBL3605501 | — | — | 1 | 6.70 |
| CHEMBL3605415 | — | — | 1 | 6.62 |
| CHEMBL3605497 | — | — | 1 | 6.62 |
| CHEMBL3605500 | — | — | 1 | 6.58 |
| CHEMBL3605499 | — | — | 1 | 6.54 |
| CHEMBL3605416 | — | — | 1 | 6.42 |
| CHEMBL3605503 | — | — | 1 | 6.41 |
| CHEMBL3605494 | — | — | 1 | 6.28 |
| CHEMBL3605493 | — | — | 1 | 6.16 |
| CHEMBL3605417 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605502 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3605507 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3605506 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3605495 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3605508 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3605496 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3605501 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3605415 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3605497 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3605500 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3605499 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3605416 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3605503 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3605494 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3605493 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3605417 | — | IC50 | = | 1200.0 | nM | 5.92 |