Assay Detail
Binding
CHEMBL3606871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SUMO-tagged ULK1 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubated for 7 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KRX |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK1 (CHEMBL6006) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.24 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605055 | — | — | 1 | 8.28 |
| CHEMBL3603853 | — | — | 1 | 7.17 |
| CHEMBL577784 | BX-795 | — | 1 | 7.06 |
| CHEMBL3605056 | — | — | 1 | 6.92 |
| CHEMBL3605057 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605055 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3603853 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL577784 | BX-795 | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3605056 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3605057 | — | IC50 | = | 170.0 | nM | 6.77 |