Assay Detail
Binding
CHEMBL3606872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SUMO-tagged ULK2 (unknown origin) kinase domain expressed in KRX cells using [32P]-gamma-ATP and myelin basic protein substrate incubated for 7 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KRX |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK2 (CHEMBL5435) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.84 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605055 | — | — | 1 | 7.89 |
| CHEMBL3603853 | — | — | 1 | 6.70 |
| CHEMBL3605057 | — | — | 1 | 6.64 |
| CHEMBL577784 | BX-795 | — | 1 | 6.51 |
| CHEMBL3605056 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605055 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3603853 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3605057 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL577784 | BX-795 | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3605056 | — | IC50 | = | 360.0 | nM | 6.44 |