Assay Detail
Binding
CHEMBL3606873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant PDK1 (unknown origin) using PDK1tide substrate incubated for 7 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (CHEMBL4766) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.67 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3603853 | — | — | 1 | 7.25 |
| CHEMBL577784 | BX-795 | — | 1 | 7.19 |
| CHEMBL3605057 | — | — | 1 | 6.38 |
| CHEMBL3605055 | — | — | 1 | 6.38 |
| CHEMBL3605056 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3603853 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL577784 | BX-795 | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3605057 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL3605055 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3605056 | — | IC50 | = | 710.0 | nM | 6.15 |