Assay Detail
Binding
CHEMBL3606997
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Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measured after 15 mins by beta plate counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.98 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190281 | — | — | 1 | 8.70 |
| CHEMBL365847 | — | — | 1 | 8.70 |
| CHEMBL189937 | — | — | 1 | 8.30 |
| CHEMBL142648 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190281 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL365847 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL189937 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL142648 | — | IC50 | = | 620.0 | nM | 6.21 |