Assay Detail
Binding
CHEMBL3607001
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Inhibition of CDK4/6 in human COLO205 cells assessed as inhibition of Rb phosphorylation after 24 hrs by propidium iodide staining-based laser-scanning fluorescence microplate cytometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.12 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604463 | — | — | 1 | 7.38 |
| CHEMBL3604464 | — | — | 1 | 7.05 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604463 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3604464 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 120.0 | nM | 6.92 |