Assay Detail
Functional
CHEMBL3607084
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Antiviral activity against HCMV infected in HFF after 3 days by neutral red dye-based plaque reduction assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2- and 3-Fluoro-3-deazaneplanocins, 2-fluoro-3-deazaaristeromycins, and 3-methyl-3-deazaneplanocin: Synthesis and antiviral properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.50 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604361 | — | — | 1 | 6.52 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.44 |
| CHEMBL3604362 | — | — | 1 | 5.29 |
| CHEMBL3603846 | — | — | 1 | 5.19 |
| CHEMBL3604363 | — | — | 1 | 5.06 |
| CHEMBL3604364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604361 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3604362 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3603846 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3604363 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3604364 | — | IC50 | < | 100.0 | nM | - |