Assay Detail
Functional
CHEMBL3607328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC3 cells after 5 days by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.85 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.57 |
| CHEMBL2171637 | — | — | 1 | 7.04 |
| CHEMBL2171638 | — | — | 1 | 5.69 |
| CHEMBL3605305 | — | — | 1 | 5.57 |
| CHEMBL3605306 | — | — | 1 | 5.57 |
| CHEMBL3605304 | — | — | 1 | 5.56 |
| CHEMBL3605307 | — | — | 1 | 5.56 |
| CHEMBL3605301 | — | — | 1 | 5.49 |
| CHEMBL3605302 | — | — | 1 | 5.31 |
| CHEMBL3605303 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2171637 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL2171638 | — | IC50 | = | 2021.0 | nM | 5.69 |
| CHEMBL3605305 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3605306 | — | IC50 | = | 2706.0 | nM | 5.57 |
| CHEMBL3605304 | — | IC50 | = | 2768.0 | nM | 5.56 |
| CHEMBL3605307 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL3605301 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL3605302 | — | IC50 | = | 4855.0 | nM | 5.31 |
| CHEMBL3605303 | — | IC50 | = | 6562.0 | nM | 5.18 |