Assay Detail
Functional
CHEMBL3607331
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Cytotoxicity against human PC3 cells after 7 days by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.93 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.54 |
| CHEMBL2171637 | — | — | 1 | 7.06 |
| CHEMBL3605304 | — | — | 1 | 5.82 |
| CHEMBL2171638 | — | — | 1 | 5.81 |
| CHEMBL3605306 | — | — | 1 | 5.72 |
| CHEMBL3605307 | — | — | 1 | 5.62 |
| CHEMBL3605305 | — | — | 1 | 5.57 |
| CHEMBL3605301 | — | — | 1 | 5.52 |
| CHEMBL3605302 | — | — | 1 | 5.36 |
| CHEMBL3605303 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2171637 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3605304 | — | IC50 | = | 1507.0 | nM | 5.82 |
| CHEMBL2171638 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL3605306 | — | IC50 | = | 1902.0 | nM | 5.72 |
| CHEMBL3605307 | — | IC50 | = | 2378.0 | nM | 5.62 |
| CHEMBL3605305 | — | IC50 | = | 2692.0 | nM | 5.57 |
| CHEMBL3605301 | — | IC50 | = | 3027.0 | nM | 5.52 |
| CHEMBL3605302 | — | IC50 | = | 4355.0 | nM | 5.36 |
| CHEMBL3605303 | — | IC50 | = | 5201.0 | nM | 5.28 |