Assay Detail
Binding
CHEMBL3607369
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Binding affinity to recombinant human HisGST-tagged PARP-1 catalytic domain by surface plasmon resonance analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.28 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 9.62 |
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 8.77 |
| CHEMBL3606021 | — | — | 1 | 8.07 |
| CHEMBL3606018 | — | — | 1 | 7.80 |
| CHEMBL3605992 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521686 | OLAPARIB | Kd | = | 0.24 | nM | 9.62 |
| CHEMBL506871 | VELIPARIB | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL3606021 | — | Kd | = | 8.6 | nM | 8.07 |
| CHEMBL3606018 | — | Kd | = | 15.7 | nM | 7.80 |
| CHEMBL3605992 | — | Kd | = | 75.0 | nM | 7.12 |