Assay Detail
Binding
CHEMBL3607519
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate after 2 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Testis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 3 (CHEMBL1075158) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.26 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1813731 | — | — | 1 | 7.89 |
| CHEMBL3605211 | — | — | 1 | 7.55 |
| CHEMBL3605212 | — | — | 1 | 7.06 |
| CHEMBL87285 | ANDROSTERONE | — | 1 | 7.05 |
| CHEMBL274826 | ANDROSTENEDIONE | -1.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1813731 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3605211 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3605212 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL87285 | ANDROSTERONE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL274826 | ANDROSTENEDIONE | IC50 | = | 169.0 | nM | 6.77 |