Assay Detail
Functional
CHEMBL3607575
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Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.15 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | 8.30 |
| CHEMBL2058036 | — | — | 1 | 8.10 |
| CHEMBL2058034 | — | — | 1 | 7.96 |
| CHEMBL2057721 | — | — | 1 | 7.92 |
| CHEMBL2057722 | — | — | 1 | 7.89 |
| CHEMBL2058040 | — | — | 1 | 7.68 |
| CHEMBL2058033 | — | — | 1 | 7.40 |
| CHEMBL2058041 | — | — | 1 | 7.39 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.31 |
| CHEMBL3604374 | — | — | 1 | 6.72 |
| CHEMBL2058039 | — | — | 1 | 6.70 |
| CHEMBL2058035 | — | — | 1 | 6.31 |
| CHEMBL2058037 | — | — | 1 | 6.30 |
| CHEMBL2057720 | — | — | 1 | 5.94 |
| CHEMBL2058038 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL682 | AMODIAQUINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2058036 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2058034 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2057721 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2057722 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2058040 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2058033 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2058041 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3604374 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL2058039 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2058035 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL2058037 | — | IC50 | = | 501.0 | nM | 6.30 |
| CHEMBL2057720 | — | IC50 | = | 1158.0 | nM | 5.94 |
| CHEMBL2058038 | — | IC50 | = | 4580.0 | nM | 5.34 |