Assay Detail
Functional
CHEMBL3607576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.67 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2057722 | — | — | 1 | 8.15 |
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | 8.10 |
| CHEMBL2057721 | — | — | 1 | 7.85 |
| CHEMBL2058036 | — | — | 1 | 7.66 |
| CHEMBL3604376 | — | — | 1 | 7.62 |
| CHEMBL2058033 | — | — | 1 | 7.60 |
| CHEMBL3604377 | — | — | 1 | 7.41 |
| CHEMBL3604382 | — | — | 1 | 7.38 |
| CHEMBL3604380 | — | — | 1 | 7.38 |
| CHEMBL2058041 | — | — | 1 | 7.14 |
| CHEMBL3604379 | — | — | 1 | 7.10 |
| CHEMBL3604381 | — | — | 1 | 7.07 |
| CHEMBL2058038 | — | — | 1 | 7.05 |
| CHEMBL2058040 | — | — | 1 | 7.04 |
| CHEMBL3604392 | — | — | 1 | 7.00 |
| CHEMBL3604383 | — | — | 1 | 6.83 |
| CHEMBL3604378 | — | — | 1 | 6.70 |
| CHEMBL3604384 | — | — | 1 | 6.65 |
| CHEMBL3604390 | — | — | 1 | 6.62 |
| CHEMBL2058037 | — | — | 1 | 6.60 |
| CHEMBL3604385 | — | — | 1 | 6.55 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.46 |
| CHEMBL3604395 | — | — | 1 | 6.39 |
| CHEMBL3604394 | — | — | 1 | 6.38 |
| CHEMBL3604388 | — | — | 1 | 6.15 |
| CHEMBL3604374 | — | — | 1 | 6.13 |
| CHEMBL3604375 | — | — | 1 | 6.11 |
| CHEMBL2058039 | — | — | 1 | 6.08 |
| CHEMBL3604387 | — | — | 1 | 6.07 |
| CHEMBL3604393 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2057722 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL682 | AMODIAQUINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2057721 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2058036 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3604376 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2058033 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3604377 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3604382 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3604380 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2058041 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3604379 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3604381 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2058038 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2058040 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3604392 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3604383 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL3604378 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL3604384 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL3604390 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2058037 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL3604385 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL3604395 | — | IC50 | = | 411.0 | nM | 6.39 |
| CHEMBL3604394 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL3604388 | — | IC50 | = | 704.0 | nM | 6.15 |
| CHEMBL3604374 | — | IC50 | = | 742.0 | nM | 6.13 |
| CHEMBL3604375 | — | IC50 | = | 773.0 | nM | 6.11 |
| CHEMBL2058039 | — | IC50 | = | 827.0 | nM | 6.08 |
| CHEMBL3604387 | — | IC50 | = | 851.0 | nM | 6.07 |
| CHEMBL3604393 | — | IC50 | = | 875.0 | nM | 6.06 |
| CHEMBL3604386 | — | IC50 | = | 883.0 | nM | 6.05 |
| CHEMBL2057720 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL2058035 | — | IC50 | = | 921.0 | nM | 6.04 |
| CHEMBL3604391 | — | IC50 | = | 1379.0 | nM | 5.86 |
| CHEMBL3604389 | — | IC50 | = | 1553.0 | nM | 5.81 |
| CHEMBL3604396 | — | IC50 | = | 2111.0 | nM | 5.68 |
| CHEMBL3604397 | — | IC50 | = | 2928.0 | nM | 5.53 |
| CHEMBL3604398 | — | IC50 | = | 10992.0 | nM | 4.96 |
| CHEMBL2058034 | — | IC50 | - | — | - | |
| CHEMBL3604399 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3604400 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3604401 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL245075 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3604402 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3604403 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL50588 | EMETINE | IC50 | - | — | - |