Assay Detail
Functional
CHEMBL3607578
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.02 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL682 | AMODIAQUINE | 4.0 | 1 | 8.40 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.00 |
| CHEMBL3604376 | — | — | 1 | 8.00 |
| CHEMBL3604377 | — | — | 1 | 8.00 |
| CHEMBL3604380 | — | — | 1 | 7.96 |
| CHEMBL3604382 | — | — | 1 | 7.92 |
| CHEMBL3604381 | — | — | 1 | 7.85 |
| CHEMBL2058036 | — | — | 1 | 7.82 |
| CHEMBL3604383 | — | — | 1 | 7.72 |
| CHEMBL3604379 | — | — | 1 | 7.41 |
| CHEMBL3604392 | — | — | 1 | 7.29 |
| CHEMBL3604378 | — | — | 1 | 6.97 |
| CHEMBL3604385 | — | — | 1 | 6.97 |
| CHEMBL3604384 | — | — | 1 | 6.91 |
| CHEMBL3604390 | — | — | 1 | 6.84 |
| CHEMBL3604394 | — | — | 1 | 6.70 |
| CHEMBL3604395 | — | — | 1 | 6.67 |
| CHEMBL3604393 | — | — | 1 | 6.56 |
| CHEMBL3604388 | — | — | 1 | 6.51 |
| CHEMBL3604387 | — | — | 1 | 6.40 |
| CHEMBL3604386 | — | — | 1 | 6.39 |
| CHEMBL2058035 | — | — | 1 | 6.33 |
| CHEMBL3604391 | — | — | 1 | 6.29 |
| CHEMBL3604389 | — | — | 1 | 6.20 |
| CHEMBL3604396 | — | — | 1 | 5.96 |
| CHEMBL3604397 | — | — | 1 | 5.79 |
| CHEMBL3604375 | — | — | 1 | 5.73 |
| CHEMBL3604398 | — | — | 1 | - |
| CHEMBL3604399 | — | — | 1 | - |
| CHEMBL3604400 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL682 | AMODIAQUINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3604377 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3604376 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3604380 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3604382 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3604381 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2058036 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3604383 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3604379 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3604392 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3604378 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL3604385 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3604384 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL3604390 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL3604394 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL3604395 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL3604393 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL3604388 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL3604387 | — | IC50 | = | 402.0 | nM | 6.40 |
| CHEMBL3604386 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL2058035 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL3604391 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL3604389 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3604396 | — | IC50 | = | 1094.0 | nM | 5.96 |
| CHEMBL3604397 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL3604375 | — | IC50 | = | 1876.0 | nM | 5.73 |
| CHEMBL3604398 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3604399 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3604400 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3604401 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL245075 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3604402 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3604403 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL50588 | EMETINE | IC50 | - | — | - |