Assay Detail
Binding
CHEMBL3607766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BAF |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ribosomal protein S6 kinase alpha-3 (CHEMBL3297641) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 5.86 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604792 | — | — | 1 | 6.85 |
| CHEMBL3604794 | — | — | 1 | 6.68 |
| CHEMBL3604793 | — | — | 1 | 6.47 |
| CHEMBL3604885 | — | — | 1 | 6.44 |
| CHEMBL3604881 | — | — | 1 | 6.36 |
| CHEMBL3604784 | — | — | 1 | 6.31 |
| CHEMBL3604889 | — | — | 1 | 6.30 |
| CHEMBL3604882 | — | — | 1 | 6.24 |
| CHEMBL3604888 | — | — | 1 | 6.21 |
| CHEMBL3604884 | — | — | 1 | 6.16 |
| CHEMBL3604886 | — | — | 1 | 6.16 |
| CHEMBL3604785 | — | — | 1 | 5.96 |
| CHEMBL3604787 | — | — | 1 | 5.96 |
| CHEMBL3604790 | — | — | 1 | 5.96 |
| CHEMBL3604775 | — | — | 1 | 5.85 |
| CHEMBL3604887 | — | — | 1 | 5.82 |
| CHEMBL3604789 | — | — | 1 | 5.80 |
| CHEMBL3604791 | — | — | 1 | 5.68 |
| CHEMBL3604779 | — | — | 1 | 5.66 |
| CHEMBL3604786 | — | — | 1 | 5.64 |
| CHEMBL3604883 | — | — | 1 | 5.60 |
| CHEMBL3604771 | — | — | 1 | 5.55 |
| CHEMBL3604774 | — | — | 1 | 5.50 |
| CHEMBL3604782 | — | — | 1 | 5.39 |
| CHEMBL3604778 | — | — | 1 | 5.38 |
| CHEMBL3604795 | — | — | 1 | 5.28 |
| CHEMBL3604783 | — | — | 1 | 5.25 |
| CHEMBL3604777 | — | — | 1 | 5.19 |
| CHEMBL3604776 | — | — | 1 | 5.03 |
| CHEMBL3604788 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604792 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3604794 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3604793 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3604885 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3604881 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3604784 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3604889 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3604882 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3604888 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3604884 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3604886 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3604785 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3604787 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3604790 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3604775 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3604887 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3604789 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3604791 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3604779 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3604786 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3604883 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3604771 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3604774 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3604782 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3604778 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3604795 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3604783 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3604777 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3604776 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3604788 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL3604796 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3604772 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3604773 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3604780 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3604781 | — | EC50 | > | 20000.0 | nM | - |