Assay Detail
Functional
CHEMBL3607897
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Antiplasmodial activity against CQ-resistant Plasmodium falciparum Dd2
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinoline-based antimalarial hybrid compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 6 | - | - |
| IC50 | 4 | 7.17 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220692 | — | — | 1 | 7.48 |
| CHEMBL221654 | — | — | 1 | 7.48 |
| CHEMBL221655 | — | — | 1 | 7.48 |
| CHEMBL3219153 | — | — | 1 | 6.24 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
| CHEMBL1254047 | — | — | 1 | - |
| CHEMBL1254138 | — | — | 1 | - |
| CHEMBL1254628 | — | — | 1 | - |
| CHEMBL1254629 | — | — | 1 | - |
| CHEMBL1254794 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220692 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL221654 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL221655 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3219153 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL76 | CHLOROQUINE | Activity | = | 102.0 | nM | - |
| CHEMBL1254047 | — | Activity | = | 1.0 | nM | - |
| CHEMBL1254138 | — | Activity | = | 1.0 | nM | - |
| CHEMBL1254628 | — | Activity | = | 1.0 | nM | - |
| CHEMBL1254629 | — | Activity | = | 1.0 | nM | - |
| CHEMBL1254794 | — | Activity | = | 1.0 | nM | - |