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Assay Detail

CHEMBL3608011

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human carbonic anhydrase-2 incubated for 15 mins by stopped-flow CO2 hydration assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.
Mollica A, Costante R, Akdemir A, Carradori S, Stefanucci A, Macedonio G, Ceruso M, Supuran CT.
Bioorg Med Chem (2015) 23 : 5311 -5318
PubMed 26264840 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 6.47 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.92
CHEMBL3604509 1 7.89
CHEMBL3604416 1 7.80
CHEMBL3604411 1 7.01
CHEMBL897 PROBENECID 4.0 1 6.37
CHEMBL3604413 1 6.29
CHEMBL3604412 1 6.15
CHEMBL3604410 1 6.10
CHEMBL3604409 1 6.03
CHEMBL3604415 1 6.02
CHEMBL3604414 1 5.03
CHEMBL3604404 1 5.01
CHEMBL3604512 1 -
CHEMBL3604405 1 -
CHEMBL3604406 1 -
CHEMBL3604407 1 -
CHEMBL3604408 1 -
CHEMBL3604511 1 -
CHEMBL3604510 1 -
CHEMBL3604515 1 -
CHEMBL3604513 1 -
CHEMBL3604420 1 -
CHEMBL3604419 1 -
CHEMBL3604418 1 -
CHEMBL3604514 1 -
CHEMBL3604417 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE Ki = 12.0 nM 7.92
CHEMBL3604509 Ki = 13.0 nM 7.89
CHEMBL3604416 Ki = 16.0 nM 7.80
CHEMBL3604411 Ki = 98.0 nM 7.01
CHEMBL897 PROBENECID Ki = 431.0 nM 6.37
CHEMBL3604413 Ki = 507.0 nM 6.29
CHEMBL3604412 Ki = 707.0 nM 6.15
CHEMBL3604410 Ki = 788.0 nM 6.10
CHEMBL3604409 Ki = 942.0 nM 6.03
CHEMBL3604415 Ki = 958.0 nM 6.02
CHEMBL3604414 Ki = 9338.0 nM 5.03
CHEMBL3604404 Ki = 9829.0 nM 5.01
CHEMBL3604512 Ki > 10000.0 nM -
CHEMBL3604405 Ki > 10000.0 nM -
CHEMBL3604406 Ki > 10000.0 nM -
CHEMBL3604407 Ki > 10000.0 nM -
CHEMBL3604408 Ki > 10000.0 nM -
CHEMBL3604511 Ki > 10000.0 nM -
CHEMBL3604510 Ki > 10000.0 nM -
CHEMBL3604515 Ki > 10000.0 nM -
CHEMBL3604513 Ki > 10000.0 nM -
CHEMBL3604420 Ki > 10000.0 nM -
CHEMBL3604419 Ki > 10000.0 nM -
CHEMBL3604418 Ki > 10000.0 nM -
CHEMBL3604514 Ki > 10000.0 nM -
CHEMBL3604417 Ki > 10000.0 nM -