Assay Detail
Binding
CHEMBL3608013
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Inhibition of human carbonic anhydrase-12 incubated for 15 mins by stopped-flow CO2 hydration assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.36 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL3604409 | — | — | 1 | 8.06 |
| CHEMBL3604411 | — | — | 1 | 8.05 |
| CHEMBL3604412 | — | — | 1 | 8.04 |
| CHEMBL3604410 | — | — | 1 | 8.02 |
| CHEMBL3604415 | — | — | 1 | 7.96 |
| CHEMBL3604408 | — | — | 1 | 7.96 |
| CHEMBL3604420 | — | — | 1 | 7.92 |
| CHEMBL3604513 | — | — | 1 | 7.92 |
| CHEMBL3604512 | — | — | 1 | 7.92 |
| CHEMBL3604511 | — | — | 1 | 7.92 |
| CHEMBL3604510 | — | — | 1 | 7.92 |
| CHEMBL3604515 | — | — | 1 | 7.37 |
| CHEMBL3604419 | — | — | 1 | 7.31 |
| CHEMBL3604414 | — | — | 1 | 7.28 |
| CHEMBL3604407 | — | — | 1 | 7.22 |
| CHEMBL3604509 | — | — | 1 | 7.11 |
| CHEMBL3604514 | — | — | 1 | 7.10 |
| CHEMBL3604418 | — | — | 1 | 7.00 |
| CHEMBL3604417 | — | — | 1 | 6.94 |
| CHEMBL3604413 | — | — | 1 | 6.56 |
| CHEMBL3604416 | — | — | 1 | 6.13 |
| CHEMBL3604405 | — | — | 1 | 6.07 |
| CHEMBL3604406 | — | — | 1 | 6.02 |
| CHEMBL897 | PROBENECID | 4.0 | 1 | 5.91 |
| CHEMBL3604404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL3604409 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL3604411 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL3604412 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL3604410 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL3604415 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3604408 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3604420 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3604513 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3604512 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3604511 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3604510 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3604515 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3604419 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL3604414 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL3604407 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3604509 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL3604514 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL3604418 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL3604417 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL3604413 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL3604416 | — | Ki | = | 742.0 | nM | 6.13 |
| CHEMBL3604405 | — | Ki | = | 851.0 | nM | 6.07 |
| CHEMBL3604406 | — | Ki | = | 961.0 | nM | 6.02 |
| CHEMBL897 | PROBENECID | Ki | = | 1245.0 | nM | 5.91 |
| CHEMBL3604404 | — | Ki | > | 10000.0 | nM | - |