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Assay Detail

CHEMBL3608045

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human MAOB
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New Frontiers in Selective Human MAO-B Inhibitors.
Carradori S, Silvestri R.
J Med Chem (2015) 58 : 6717 -6732
PubMed 25915162 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 7.33 9.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2333930 1 9.89
CHEMBL3604126 1 7.66
CHEMBL3604128 1 7.50
CHEMBL3219618 1 7.40
CHEMBL1806760 1 7.21
CHEMBL602464 1 7.17
CHEMBL1984524 1 7.16
CHEMBL3604127 1 4.66
CHEMBL113 CAFFEINE 4.0 1 -
CHEMBL198810 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2333930 Ki = 0.129 nM 9.89
CHEMBL3604126 Ki = 22.0 nM 7.66
CHEMBL3604128 Ki = 32.0 nM 7.50
CHEMBL3219618 Ki = 40.0 nM 7.40
CHEMBL1806760 Ki = 62.0 nM 7.21
CHEMBL602464 Ki = 68.0 nM 7.17
CHEMBL1984524 Ki = 70.0 nM 7.16
CHEMBL3604127 Ki = 22000.0 nM 4.66
CHEMBL113 CAFFEINE Ki = 3800000.0 nM -
CHEMBL198810 Ki = 0.6 nM -