Assay Detail
Binding
CHEMBL3608122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NR1-1a/NR2B expressed in mouse L13-E6 cells assessed as inhibition of glutamate-induced excitotoxicity incubated for 16 hrs by LDH release assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | L13-E6 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; GRIN1/GRIN2B (CHEMBL1907603) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.34 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3605361 | — | — | 1 | 6.11 |
| CHEMBL3605360 | — | — | 1 | 5.82 |
| CHEMBL3605365 | — | — | 1 | 5.70 |
| CHEMBL3605363 | — | — | 1 | 5.58 |
| CHEMBL3605364 | — | — | 1 | 5.55 |
| CHEMBL1198953 | — | — | 1 | 5.54 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 5.28 |
| CHEMBL3605359 | — | — | 1 | 5.14 |
| CHEMBL3605362 | — | — | 1 | 5.13 |
| CHEMBL3605358 | — | — | 1 | 4.51 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 4.36 |
| CHEMBL3605355 | — | — | 1 | - |
| CHEMBL3605354 | — | — | 1 | - |
| CHEMBL3605353 | — | — | 1 | - |
| CHEMBL1087459 | — | — | 1 | - |
| CHEMBL1098471 | — | — | 1 | - |
| CHEMBL3605366 | — | — | 1 | - |
| CHEMBL3605367 | — | — | 1 | - |
| CHEMBL3605368 | — | — | 1 | - |
| CHEMBL3605369 | — | — | 1 | - |
| CHEMBL3605370 | — | — | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | - |
| CHEMBL3605356 | — | — | 1 | - |
| CHEMBL3605357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3605361 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3605360 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3605365 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3605363 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3605364 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1198953 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL807 | MEMANTINE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3605359 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3605362 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3605358 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL95 | TACRINE | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL3605355 | — | IC50 | - | — | - | |
| CHEMBL3605354 | — | IC50 | - | — | - | |
| CHEMBL3605353 | — | IC50 | - | — | - | |
| CHEMBL1087459 | — | IC50 | - | — | - | |
| CHEMBL1098471 | — | IC50 | - | — | - | |
| CHEMBL3605366 | — | IC50 | - | — | - | |
| CHEMBL3605367 | — | IC50 | - | — | - | |
| CHEMBL3605368 | — | IC50 | - | — | - | |
| CHEMBL3605369 | — | IC50 | - | — | - | |
| CHEMBL3605370 | — | IC50 | - | — | - | |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - | |
| CHEMBL972 | SELEGILINE | IC50 | - | — | - | |
| CHEMBL3605356 | — | IC50 | - | — | - | |
| CHEMBL3605357 | — | IC50 | - | — | - |