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Assay Detail

CHEMBL3608160

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Functional
Antiproliferative activity against human MV4-11 cells after 72 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and antiproliferative activity of new bioconjugates of Salinomycin with amino acid esters.
Antoszczak M, Sobusiak M, Maj E, Wietrzyk J, Huczyński A.
Bioorg Med Chem Lett (2015) 25 : 3511 -3514
PubMed 26163197 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 5.94 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 7.30
CHEMBL1208572 SALINOMYCIN 2.0 1 6.48
CHEMBL3605174 1 6.10
CHEMBL3605175 1 5.54
CHEMBL3605176 1 5.45
CHEMBL3605172 1 5.44
CHEMBL3605173 1 5.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 50.0 nM 7.30
CHEMBL1208572 SALINOMYCIN IC50 = 330.0 nM 6.48
CHEMBL3605174 IC50 = 800.0 nM 6.10
CHEMBL3605175 IC50 = 2890.0 nM 5.54
CHEMBL3605176 IC50 = 3550.0 nM 5.45
CHEMBL3605172 IC50 = 3650.0 nM 5.44
CHEMBL3605173 IC50 = 5810.0 nM 5.24