Assay Detail

CHEMBL3610108

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to monkey NK3R

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Macaca mulatta
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II).

Hoveyda HR, Fraser GL, Dutheuil G, El Bousmaqui M, Korac J, Lenoir F, Lapin A, Noël S.
ACS Med Chem Lett (2015) 6 : 736 -740
PubMed 26191358 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	7.65	7.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3422010	—	—	1	7.70
CHEMBL3608680	FEZOLINETANT	4.0	1	7.60

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3422010	—	Ki	=	20.0	nM	7.70
CHEMBL3608680	FEZOLINETANT	Ki	=	25.0	nM	7.60