Assay Detail
Binding
CHEMBL3610296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by IonWorks assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.59 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318989 | — | — | 1 | 6.00 |
| CHEMBL3290336 | — | — | 1 | 4.64 |
| CHEMBL3608757 | — | — | 1 | 4.12 |
| CHEMBL3608750 | — | — | 1 | 4.10 |
| CHEMBL3608744 | — | — | 1 | 4.09 |
| CHEMBL3608742 | — | — | 1 | - |
| CHEMBL3608743 | — | — | 1 | - |
| CHEMBL3608314 | — | — | 1 | - |
| CHEMBL3608745 | — | — | 1 | - |
| CHEMBL3608746 | — | — | 1 | - |
| CHEMBL3608747 | — | — | 1 | - |
| CHEMBL3608749 | — | — | 1 | - |
| CHEMBL3608751 | — | — | 1 | - |
| CHEMBL3608752 | — | — | 1 | - |
| CHEMBL3608753 | — | — | 1 | - |
| CHEMBL3608754 | — | — | 1 | - |
| CHEMBL3608755 | — | — | 1 | - |
| CHEMBL3608756 | — | — | 1 | - |
| CHEMBL3608748 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318989 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3290336 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3608757 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL3608750 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL3608744 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL3608742 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL3608743 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608314 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL3608745 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608746 | — | IC50 | > | 224000.0 | nM | - |
| CHEMBL3608747 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608749 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608751 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608752 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608753 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608754 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608755 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608756 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608748 | — | IC50 | > | 100000.0 | nM | - |