Assay Detail
Binding
CHEMBL3610380
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probing the 'bipolar' nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.22 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608890 | — | — | 1 | 8.44 |
| CHEMBL3608887 | — | — | 1 | 8.29 |
| CHEMBL3608871 | — | — | 1 | 8.21 |
| CHEMBL3608892 | — | — | 1 | 8.18 |
| CHEMBL3608888 | — | — | 1 | 8.17 |
| CHEMBL3608874 | — | — | 1 | 8.16 |
| CHEMBL3608870 | — | — | 1 | 8.07 |
| CHEMBL3608872 | — | — | 1 | 8.06 |
| CHEMBL3608891 | — | — | 1 | 8.06 |
| CHEMBL3608894 | — | — | 1 | 8.04 |
| CHEMBL3608886 | — | — | 1 | 8.04 |
| CHEMBL3608885 | — | — | 1 | 8.03 |
| CHEMBL3608889 | — | — | 1 | 7.52 |
| CHEMBL3608873 | — | — | 1 | 7.37 |
| CHEMBL3608880 | — | — | 1 | 7.20 |
| CHEMBL3608893 | — | — | 1 | 7.19 |
| CHEMBL3608875 | — | — | 1 | 6.61 |
| CHEMBL3608876 | — | — | 1 | 6.42 |
| CHEMBL3608882 | — | — | 1 | 6.25 |
| CHEMBL3608877 | — | — | 1 | 5.86 |
| CHEMBL3608881 | — | — | 1 | 5.55 |
| CHEMBL3608878 | — | — | 1 | 5.45 |
| CHEMBL3608879 | — | — | 1 | 5.10 |
| CHEMBL3608883 | — | — | 1 | 5.07 |
| CHEMBL3608884 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608890 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL3608887 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL3608871 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL3608892 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL3608888 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL3608874 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL3608870 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL3608872 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3608891 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3608894 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3608886 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3608885 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL3608889 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL3608873 | — | Ki | = | 42.3 | nM | 7.37 |
| CHEMBL3608880 | — | Ki | = | 62.8 | nM | 7.20 |
| CHEMBL3608893 | — | Ki | = | 64.4 | nM | 7.19 |
| CHEMBL3608875 | — | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL3608876 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL3608882 | — | Ki | = | 557.0 | nM | 6.25 |
| CHEMBL3608877 | — | Ki | = | 1395.0 | nM | 5.86 |
| CHEMBL3608881 | — | Ki | = | 2790.0 | nM | 5.55 |
| CHEMBL3608878 | — | Ki | = | 3535.0 | nM | 5.45 |
| CHEMBL3608879 | — | Ki | = | 7960.0 | nM | 5.10 |
| CHEMBL3608883 | — | Ki | = | 8570.0 | nM | 5.07 |
| CHEMBL3608884 | — | Ki | > | 10000.0 | nM | - |