Assay Detail
Binding
CHEMBL3610545
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Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.19 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.25 |
| CHEMBL3609481 | — | — | 1 | 7.77 |
| CHEMBL3609482 | — | — | 1 | 7.75 |
| CHEMBL3609200 | — | — | 1 | 7.42 |
| CHEMBL3609198 | — | — | 1 | 7.33 |
| CHEMBL3609197 | — | — | 1 | 7.31 |
| CHEMBL3609195 | — | — | 1 | 7.20 |
| CHEMBL3609199 | — | — | 1 | 7.04 |
| CHEMBL3609475 | — | — | 1 | 6.95 |
| CHEMBL3609477 | — | — | 1 | 6.92 |
| CHEMBL3609201 | — | — | 1 | 6.89 |
| CHEMBL3609478 | — | — | 1 | 6.84 |
| CHEMBL1736901 | — | — | 1 | 6.83 |
| CHEMBL3609476 | — | — | 1 | 6.82 |
| CHEMBL3609196 | — | — | 1 | 6.78 |
| CHEMBL3609480 | — | — | 1 | 6.75 |
| CHEMBL1714980 | — | — | 1 | 6.74 |
| CHEMBL3609479 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL3609481 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL3609482 | — | Ki | = | 17.8 | nM | 7.75 |
| CHEMBL3609200 | — | Ki | = | 38.1 | nM | 7.42 |
| CHEMBL3609198 | — | Ki | = | 46.5 | nM | 7.33 |
| CHEMBL3609197 | — | Ki | = | 48.6 | nM | 7.31 |
| CHEMBL3609195 | — | Ki | = | 62.5 | nM | 7.20 |
| CHEMBL3609199 | — | Ki | = | 91.4 | nM | 7.04 |
| CHEMBL3609475 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL3609477 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3609201 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL3609478 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL1736901 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL3609476 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL3609196 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL3609480 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL1714980 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL3609479 | — | Ki | = | 247.0 | nM | 6.61 |