Assay Detail
Functional
CHEMBL3610697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as reduction in viral RNA replication
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC90 | 7 | - | - |
| EC50 | 7 | 10.44 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3609804 | — | — | 2 | 10.70 |
| CHEMBL3609801 | — | — | 2 | 10.70 |
| CHEMBL3609802 | — | — | 2 | 10.52 |
| CHEMBL3609800 | — | — | 2 | 10.52 |
| CHEMBL3609799 | — | — | 2 | 10.21 |
| CHEMBL3609803 | — | — | 2 | 10.00 |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3609804 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3609801 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3609802 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3609800 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3609799 | — | EC50 | = | 0.061 | nM | 10.21 |
| CHEMBL3609803 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3609804 | — | EC90 | = | 100.0 | pM | - |
| CHEMBL3609803 | — | EC90 | = | 300.0 | pM | - |
| CHEMBL2023898 | DACLATASVIR | EC90 | = | 20.0 | pM | - |
| CHEMBL3609802 | — | EC90 | = | 100.0 | pM | - |
| CHEMBL3609801 | — | EC90 | = | 32.0 | pM | - |
| CHEMBL3609800 | — | EC90 | = | 100.0 | pM | - |
| CHEMBL3609799 | — | EC90 | = | 100.0 | pM | - |
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 0.004 | nM | - |