Assay Detail
Functional
CHEMBL3610787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 2a
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 10.47 | 10.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 10.62 |
| CHEMBL3609802 | — | — | 1 | 10.57 |
| CHEMBL3609801 | — | — | 1 | 10.41 |
| CHEMBL3609800 | — | — | 1 | 10.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 0.024 | nM | 10.62 |
| CHEMBL3609802 | — | EC50 | = | 0.027 | nM | 10.57 |
| CHEMBL3609801 | — | EC50 | = | 0.039 | nM | 10.41 |
| CHEMBL3609800 | — | EC50 | = | 0.055 | nM | 10.26 |