Assay Detail
Functional
CHEMBL3611201
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Cytotoxicity against Wnt-dependent human SW480 cells assessed as cell viability after 24 hrs by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits the Wnt signaling pathway by decreasing β-catenin mRNA expression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.97 | 4.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364613 | CORONARIDINE | — | 1 | 4.98 |
| CHEMBL360427 | ISOVOACANGINE | — | 1 | 4.95 |
| CHEMBL182120 | VOACANGINE | — | 1 | - |
| CHEMBL184480 | CORONARIDINE HYDROXYINDOLENINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364613 | CORONARIDINE | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL360427 | ISOVOACANGINE | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL182120 | VOACANGINE | IC50 | > | 40000.0 | nM | - |
| CHEMBL184480 | CORONARIDINE HYDROXYINDOLENINE | IC50 | > | 40000.0 | nM | - |