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Assay Detail

CHEMBL3611213

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human COLO205 cells incubated for 48 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type COLO 205
Confidence 1 — Organism
Curated By Autocuration

Target

COLO 205 (CHEMBL614561)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of novel 3,9-substituted β-carboline derivatives as anticancer agents.
Chen YF, Lin YC, Chen JP, Chan HC, Hsu MH, Lin HY, Kuo SC, Huang LJ.
Bioorg Med Chem Lett (2015) 25 : 3873 -3877
PubMed 26235951 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.47 4.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3608818 1 4.58
CHEMBL3608807 1 4.57
CHEMBL3608815 1 4.51
CHEMBL3608816 1 4.49
CHEMBL3608817 1 4.47
CHEMBL3608808 1 4.43
CHEMBL3608811 1 4.41
CHEMBL11908 1 4.30
CHEMBL3608804 1 -
CHEMBL454606 1 -
CHEMBL3608805 1 -
CHEMBL3608806 1 -
CHEMBL3608809 1 -
CHEMBL3608810 1 -
CHEMBL149177 1 -
CHEMBL3608813 1 -
CHEMBL1178063 1 -
CHEMBL3608814 1 -
CHEMBL417982 1 -
CHEMBL333985 1 -
CHEMBL3608812 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3608818 IC50 = 26500.0 nM 4.58
CHEMBL3608807 IC50 = 26700.0 nM 4.57
CHEMBL3608815 IC50 = 31000.0 nM 4.51
CHEMBL3608816 IC50 = 32500.0 nM 4.49
CHEMBL3608817 IC50 = 33500.0 nM 4.47
CHEMBL3608808 IC50 = 36900.0 nM 4.43
CHEMBL3608811 IC50 = 38700.0 nM 4.41
CHEMBL11908 IC50 = 49600.0 nM 4.30
CHEMBL3608804 IC50 > 50000.0 nM -
CHEMBL454606 IC50 > 100000.0 nM -
CHEMBL3608805 IC50 > 100000.0 nM -
CHEMBL3608806 IC50 > 100000.0 nM -
CHEMBL3608809 IC50 > 100000.0 nM -
CHEMBL3608810 IC50 > 100000.0 nM -
CHEMBL149177 IC50 > 50000.0 nM -
CHEMBL3608813 IC50 > 100000.0 nM -
CHEMBL1178063 IC50 > 100000.0 nM -
CHEMBL3608814 IC50 > 100000.0 nM -
CHEMBL417982 IC50 > 100000.0 nM -
CHEMBL333985 IC50 - -
CHEMBL3608812 IC50 > 100000.0 nM -