Assay Detail
Functional
CHEMBL3611292
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Cytotoxicity against human OVCAR8 cells assessed as cell viability after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrid compounds with two redox centres: modular synthesis of chalcogen-containing lapachones and studies on their antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.60 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.39 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.94 |
| CHEMBL3609556 | — | — | 1 | 5.81 |
| CHEMBL3609563 | — | — | 1 | 5.80 |
| CHEMBL3609552 | — | — | 1 | 5.75 |
| CHEMBL3609562 | — | — | 1 | 5.65 |
| CHEMBL3609557 | — | — | 1 | 5.59 |
| CHEMBL3609560 | — | — | 1 | 5.58 |
| CHEMBL3609558 | — | — | 1 | 5.56 |
| CHEMBL3609559 | — | — | 1 | 5.55 |
| CHEMBL3609555 | — | — | 1 | 5.46 |
| CHEMBL3609554 | — | — | 1 | 5.32 |
| CHEMBL3609561 | — | — | 1 | 5.17 |
| CHEMBL3609553 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL3609556 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL3609563 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL3609552 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL3609562 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL3609557 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL3609560 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL3609558 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL3609559 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL3609555 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL3609554 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL3609561 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3609553 | — | IC50 | = | 15480.0 | nM | 4.81 |