Assay Detail
Functional
CHEMBL3611294
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Cytotoxicity against human MDA-MB-435 cells assessed as cell viability after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrid compounds with two redox centres: modular synthesis of chalcogen-containing lapachones and studies on their antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.61 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.60 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.02 |
| CHEMBL3609556 | — | — | 1 | 5.89 |
| CHEMBL3609562 | — | — | 1 | 5.68 |
| CHEMBL3609552 | — | — | 1 | 5.65 |
| CHEMBL3609563 | — | — | 1 | 5.63 |
| CHEMBL3609557 | — | — | 1 | 5.62 |
| CHEMBL3609555 | — | — | 1 | 5.46 |
| CHEMBL3609559 | — | — | 1 | 5.46 |
| CHEMBL3609560 | — | — | 1 | 5.45 |
| CHEMBL3609558 | — | — | 1 | 5.44 |
| CHEMBL3609554 | — | — | 1 | 5.39 |
| CHEMBL3609561 | — | — | 1 | 5.23 |
| CHEMBL3609553 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15192 | LAPACHONE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3609556 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3609562 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3609552 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL3609563 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL3609557 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL3609555 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL3609559 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL3609560 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL3609558 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL3609554 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL3609561 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL3609553 | — | IC50 | = | 9310.0 | nM | 5.03 |