Assay Detail
ADMET
CHEMBL3611295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PBMC assessed as cell viability after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrid compounds with two redox centres: modular synthesis of chalcogen-containing lapachones and studies on their antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.45 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.26 |
| CHEMBL3609556 | — | — | 1 | 5.69 |
| CHEMBL3609554 | — | — | 1 | 5.57 |
| CHEMBL3609560 | — | — | 1 | 5.56 |
| CHEMBL3609552 | — | — | 1 | 5.52 |
| CHEMBL3609563 | — | — | 1 | 5.47 |
| CHEMBL3609562 | — | — | 1 | 5.41 |
| CHEMBL3609559 | — | — | 1 | 5.37 |
| CHEMBL3609558 | — | — | 1 | 5.32 |
| CHEMBL3609561 | — | — | 1 | 5.29 |
| CHEMBL3609557 | — | — | 1 | 5.20 |
| CHEMBL3609555 | — | — | 1 | 5.18 |
| CHEMBL3609553 | — | — | 1 | 4.95 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3609556 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL3609554 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL3609560 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL3609552 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL3609563 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3609562 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL3609559 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL3609558 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL3609561 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL3609557 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL3609555 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL3609553 | — | IC50 | = | 11130.0 | nM | 4.95 |
| CHEMBL15192 | LAPACHONE | IC50 | > | 20630.0 | nM | - |