Assay Detail
Binding
CHEMBL3611488
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Inhibition of PI3Kgamma (unknown origin)
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.61 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2397186 | — | — | 1 | 6.64 |
| CHEMBL2396661 | ALPELISIB | 4.0 | 1 | 6.60 |
| CHEMBL2071330 | — | — | 1 | 6.06 |
| CHEMBL3608321 | — | — | 1 | 5.92 |
| CHEMBL3608927 | — | — | 1 | 5.60 |
| CHEMBL3609545 | — | — | 1 | 5.54 |
| CHEMBL3609542 | — | — | 1 | 5.52 |
| CHEMBL3608929 | — | — | 1 | 5.30 |
| CHEMBL3609538 | — | — | 1 | 5.21 |
| CHEMBL3609537 | — | — | 1 | 5.20 |
| CHEMBL3218581 | — | — | 1 | 5.10 |
| CHEMBL3608931 | — | — | 1 | 5.10 |
| CHEMBL3608930 | — | — | 1 | 5.08 |
| CHEMBL3609539 | — | — | 1 | - |
| CHEMBL3609536 | — | — | 1 | - |
| CHEMBL2071336 | — | — | 1 | - |
| CHEMBL3609541 | — | — | 1 | - |
| CHEMBL3609543 | — | — | 1 | - |
| CHEMBL3609544 | — | — | 1 | - |
| CHEMBL3608924 | — | — | 1 | - |
| CHEMBL3608925 | — | — | 1 | - |
| CHEMBL3608926 | — | — | 1 | - |
| CHEMBL3608936 | — | — | 1 | - |
| CHEMBL3608928 | — | — | 1 | - |
| CHEMBL3608932 | — | — | 1 | - |
| CHEMBL3608933 | — | — | 1 | - |
| CHEMBL3608934 | — | — | 1 | - |
| CHEMBL3609540 | — | — | 1 | - |
| CHEMBL3608935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2397186 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2396661 | ALPELISIB | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2071330 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3608321 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3608927 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3609545 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3609542 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3608929 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3609538 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3609537 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3218581 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3608931 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3608930 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3609539 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3609536 | — | IC50 | - | — | - | |
| CHEMBL2071336 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3609541 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3609543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3609544 | — | IC50 | - | — | - | |
| CHEMBL3608924 | — | IC50 | - | — | - | |
| CHEMBL3608925 | — | IC50 | - | — | - | |
| CHEMBL3608926 | — | IC50 | - | — | - | |
| CHEMBL3608936 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3608928 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3608932 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3608933 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3608934 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3609540 | — | IC50 | - | — | - | |
| CHEMBL3608935 | — | IC50 | - | — | - |