Assay Detail
Functional
CHEMBL3611510
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Agonist activity at human delta opioid receptor transfected in HN9.10 cells by [35S]GTPgammaS binding assay
20
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.64 | 9.42 |
| Emax | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608938 | — | — | 2 | 9.42 |
| CHEMBL3608939 | — | — | 2 | 8.47 |
| CHEMBL3609618 | — | — | 2 | 8.17 |
| CHEMBL3609620 | — | — | 2 | 7.92 |
| CHEMBL3609621 | — | — | 2 | 7.62 |
| CHEMBL3609615 | — | — | 2 | 7.60 |
| CHEMBL3609619 | — | — | 2 | 7.04 |
| CHEMBL3609616 | — | — | 2 | 6.82 |
| CHEMBL3608937 | — | — | 2 | 6.80 |
| CHEMBL3609617 | — | — | 2 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608938 | — | EC50 | = | 0.38 | nM | 9.42 |
| CHEMBL3608939 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3609618 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL3609620 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3609621 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3609615 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3609619 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3609616 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3608937 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3609617 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3608937 | — | Emax | = | 87.0 | % | - |
| CHEMBL3608938 | — | Emax | = | 77.0 | % | - |
| CHEMBL3608939 | — | Emax | = | 68.0 | % | - |
| CHEMBL3609615 | — | Emax | = | 41.0 | % | - |
| CHEMBL3609616 | — | Emax | = | 14.0 | % | - |
| CHEMBL3609617 | — | Emax | = | 33.0 | % | - |
| CHEMBL3609618 | — | Emax | = | 78.0 | % | - |
| CHEMBL3609619 | — | Emax | = | 36.0 | % | - |
| CHEMBL3609620 | — | Emax | = | 27.0 | % | - |
| CHEMBL3609621 | — | Emax | = | 50.0 | % | - |