Assay Detail
Binding
CHEMBL3611554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphatase activity of human SHP1 using pNPP as a substrate after 10 mins by spectrophotometer analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.09 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3609374 | — | — | 1 | 5.32 |
| CHEMBL3609375 | — | — | 1 | 5.22 |
| CHEMBL3609373 | — | — | 1 | 5.14 |
| CHEMBL3351077 | CEFSULODIN | 2.0 | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3609374 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3609375 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3609373 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3351077 | CEFSULODIN | IC50 | = | 21000.0 | nM | 4.68 |