Assay Detail
Binding
CHEMBL3611569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate Lineweaver-Burk plot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.74 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3609373 | — | — | 1 | 6.29 |
| CHEMBL3351077 | CEFSULODIN | 2.0 | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3609373 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL3351077 | CEFSULODIN | Ki | = | 6600.0 | nM | 5.18 |