Assay Detail
Binding
CHEMBL3611591
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Inhibition of ERK2 (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.93 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608588 | — | — | 1 | 11.00 |
| CHEMBL3608589 | — | — | 1 | 10.72 |
| CHEMBL3608586 | — | — | 1 | 10.59 |
| CHEMBL3590106 | ULIXERTINIB | 2.0 | 1 | 10.52 |
| CHEMBL3608462 | — | — | 1 | 10.48 |
| CHEMBL3608464 | — | — | 1 | 10.46 |
| CHEMBL3608463 | — | — | 1 | 10.40 |
| CHEMBL3608587 | — | — | 1 | 10.30 |
| CHEMBL3608591 | — | — | 1 | 9.80 |
| CHEMBL3608458 | — | — | 1 | 9.72 |
| CHEMBL3608461 | — | — | 1 | 9.72 |
| CHEMBL3608459 | — | — | 1 | 9.59 |
| CHEMBL3608460 | — | — | 1 | 8.65 |
| CHEMBL3608590 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608588 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3608589 | — | IC50 | = | 0.019 | nM | 10.72 |
| CHEMBL3608586 | — | IC50 | = | 0.026 | nM | 10.59 |
| CHEMBL3590106 | ULIXERTINIB | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3608462 | — | IC50 | = | 0.033 | nM | 10.48 |
| CHEMBL3608464 | — | IC50 | = | 0.035 | nM | 10.46 |
| CHEMBL3608463 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3608587 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL3608591 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL3608458 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL3608461 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL3608459 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL3608460 | — | IC50 | = | 2.26 | nM | 8.65 |
| CHEMBL3608590 | — | IC50 | = | 76.0 | nM | 7.12 |