Assay Detail
Binding
CHEMBL3611630
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Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.61 | 10.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3608939 | — | — | 1 | 10.38 |
| CHEMBL3609616 | — | — | 1 | 9.82 |
| CHEMBL3609620 | — | — | 1 | 9.55 |
| CHEMBL3608938 | — | — | 1 | 9.24 |
| CHEMBL3608937 | — | — | 1 | 8.80 |
| CHEMBL3609619 | — | — | 1 | 8.54 |
| CHEMBL3609615 | — | — | 1 | 8.31 |
| CHEMBL3609617 | — | — | 1 | 7.82 |
| CHEMBL3609621 | — | — | 1 | 7.04 |
| CHEMBL3609618 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3608939 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL3609616 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL3609620 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL3608938 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL3608937 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3609619 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL3609615 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL3609617 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3609621 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL3609618 | — | Ki | = | 230.0 | nM | 6.64 |