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Assay Detail

CHEMBL3611932

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Binding
Inhibition of HIV1 reverse transcriptase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Pyrroloaryls and pyrroloheteroaryls: Inhibitors of the HIV fusion/attachment, reverse transcriptase and integrase.
Patel RV, Park SW.
Bioorg Med Chem (2015) 23 : 5247 -5263
PubMed 26116177 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.71 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL316094 1 6.46
CHEMBL313804 1 6.33
CHEMBL3608737 1 6.30
CHEMBL3608736 1 6.16
CHEMBL3609278 1 6.15
CHEMBL3609279 1 6.07
CHEMBL3608739 1 5.87
CHEMBL3608733 1 5.57
CHEMBL3608734 1 5.54
CHEMBL3608735 1 5.51
CHEMBL3608728 1 5.40
CHEMBL3608732 1 5.40
CHEMBL3608731 1 5.40
CHEMBL3608730 1 5.40
CHEMBL3608729 1 5.40
CHEMBL3608727 1 5.40
CHEMBL322698 1 4.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL316094 IC50 = 350.0 nM 6.46
CHEMBL313804 IC50 = 470.0 nM 6.33
CHEMBL3608737 IC50 = 500.0 nM 6.30
CHEMBL3608736 IC50 = 700.0 nM 6.16
CHEMBL3609278 IC50 = 710.0 nM 6.15
CHEMBL3609279 IC50 = 850.0 nM 6.07
CHEMBL3608739 IC50 = 1350.0 nM 5.87
CHEMBL3608733 IC50 = 2700.0 nM 5.57
CHEMBL3608734 IC50 = 2900.0 nM 5.54
CHEMBL3608735 IC50 = 3100.0 nM 5.51
CHEMBL3608728 IC50 = 4000.0 nM 5.40
CHEMBL3608732 IC50 = 4000.0 nM 5.40
CHEMBL3608731 IC50 = 4000.0 nM 5.40
CHEMBL3608730 IC50 = 4000.0 nM 5.40
CHEMBL3608729 IC50 = 4000.0 nM 5.40
CHEMBL3608727 IC50 = 4000.0 nM 5.40
CHEMBL322698 IC50 = 19000.0 nM 4.72