Assay Detail
Binding
CHEMBL3614290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,4-Disubstituted aromatic piperazines with high 5-HT2A/D2 selectivity: Quantitative structure-selectivity investigations, docking, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.68 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.32 |
| CHEMBL217981 | — | — | 1 | 9.24 |
| CHEMBL221129 | — | — | 1 | 9.04 |
| CHEMBL221866 | — | — | 1 | 8.82 |
| CHEMBL221587 | — | — | 1 | 8.60 |
| CHEMBL220754 | — | — | 1 | 8.57 |
| CHEMBL386986 | — | — | 1 | 8.52 |
| CHEMBL425285 | — | — | 1 | 8.19 |
| CHEMBL218607 | — | — | 1 | 8.19 |
| CHEMBL3613874 | — | — | 1 | 8.17 |
| CHEMBL139600 | — | — | 1 | 8.15 |
| CHEMBL218351 | — | — | 1 | 8.15 |
| CHEMBL3613876 | — | — | 1 | 7.96 |
| CHEMBL437525 | — | — | 1 | 7.89 |
| CHEMBL373873 | — | — | 1 | 7.85 |
| CHEMBL385289 | — | — | 1 | 7.77 |
| CHEMBL3613877 | — | — | 1 | 7.75 |
| CHEMBL3613878 | — | — | 1 | 7.66 |
| CHEMBL3613880 | — | — | 1 | 7.64 |
| CHEMBL424294 | — | — | 1 | 7.60 |
| CHEMBL344677 | — | — | 1 | 7.47 |
| CHEMBL140968 | — | — | 1 | 7.46 |
| CHEMBL221843 | — | — | 1 | 7.46 |
| CHEMBL342060 | — | — | 1 | 7.24 |
| CHEMBL139926 | — | — | 1 | 7.09 |
| CHEMBL141845 | — | — | 1 | 7.07 |
| CHEMBL142020 | — | — | 1 | 7.00 |
| CHEMBL3613875 | — | — | 1 | 6.96 |
| CHEMBL3613879 | — | — | 1 | 6.89 |
| CHEMBL3613873 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL217981 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL221129 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL221866 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL221587 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL220754 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL386986 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL425285 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL218607 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL3613874 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL139600 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL218351 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL3613876 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL437525 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL373873 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL385289 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL3613877 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3613878 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3613880 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL424294 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL344677 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL140968 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL221843 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL342060 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL139926 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL141845 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL142020 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL3613875 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3613879 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3613873 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL357684 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL124444 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL143352 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL346692 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL59725 | — | Ki | = | 1000.0 | nM | 6.00 |