Assay Detail
Binding
CHEMBL3614293
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cell membranes by radioligand competition binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,4-Disubstituted aromatic piperazines with high 5-HT2A/D2 selectivity: Quantitative structure-selectivity investigations, docking, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.74 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3613873 | — | — | 1 | 7.43 |
| CHEMBL3613879 | — | — | 1 | 7.38 |
| CHEMBL3613880 | — | — | 1 | 7.12 |
| CHEMBL3613877 | — | — | 1 | 7.01 |
| CHEMBL3613874 | — | — | 1 | 6.89 |
| CHEMBL3613878 | — | — | 1 | 6.75 |
| CHEMBL3613875 | — | — | 1 | 5.85 |
| CHEMBL3613876 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3613873 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3613879 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL3613880 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL3613877 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL3613874 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3613878 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3613875 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3613876 | — | Ki | = | 3000.0 | nM | 5.52 |