Assay Detail
Binding
CHEMBL3614296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from adrenergic alpha1 receptor in porcine cerebral cortex homogenates by radioligand competition binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1,4-Disubstituted aromatic piperazines with high 5-HT2A/D2 selectivity: Quantitative structure-selectivity investigations, docking, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.80 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3613877 | — | — | 1 | 9.64 |
| CHEMBL3613878 | — | — | 1 | 9.41 |
| CHEMBL3613876 | — | — | 1 | 8.92 |
| CHEMBL3613873 | — | — | 1 | 8.82 |
| CHEMBL3613874 | — | — | 1 | 8.59 |
| CHEMBL3613880 | — | — | 1 | 8.48 |
| CHEMBL3613879 | — | — | 1 | 8.44 |
| CHEMBL3613875 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3613877 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL3613878 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL3613876 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3613873 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3613874 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL3613880 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL3613879 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL3613875 | — | Ki | = | 8.4 | nM | 8.08 |