Assay Detail
Binding
CHEMBL3614558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal thioredoxin His6-tagged full-length human menin expressed in Escherichia coli Rosetta (DE3) cells assessed as reduction in menin interaction with FITC-MBM1 peptide of MLL (4 to 15 residues) by fluorescence polarization assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.58 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586090 | — | — | 1 | 7.34 |
| CHEMBL3613789 | — | — | 1 | 7.19 |
| CHEMBL3613786 | — | — | 1 | 7.09 |
| CHEMBL3613784 | — | — | 1 | 7.04 |
| CHEMBL3613788 | — | — | 1 | 6.58 |
| CHEMBL3613790 | — | — | 1 | 6.17 |
| CHEMBL3612085 | — | — | 1 | 6.11 |
| CHEMBL3613787 | — | — | 1 | 5.92 |
| CHEMBL3613785 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586090 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3613789 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3613786 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3613784 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3613788 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3613790 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL3612085 | — | IC50 | = | 779.0 | nM | 6.11 |
| CHEMBL3613787 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3613785 | — | IC50 | = | 1653.0 | nM | 5.78 |