Assay Detail
Binding
CHEMBL3614599
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Inhibition of recombinant human MAOB using benzylamine as substrate after 30 mins by Amplex red based spectrophotometric analysis
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.29 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.05 |
| CHEMBL1339821 | — | — | 1 | 7.80 |
| CHEMBL595846 | — | — | 1 | 7.25 |
| CHEMBL3613158 | — | — | 1 | 7.24 |
| CHEMBL2013137 | — | — | 1 | 7.16 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 6.95 |
| CHEMBL1802004 | — | — | 1 | 6.84 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | — | 1 | 6.74 |
| CHEMBL423911 | — | — | 1 | 6.70 |
| CHEMBL3613273 | — | — | 1 | 6.65 |
| CHEMBL1801962 | — | — | 1 | 6.60 |
| CHEMBL3613271 | — | — | 1 | 6.55 |
| CHEMBL2236844 | — | — | 1 | 6.38 |
| CHEMBL34398 | 4'-METHOXYCHALCONE | — | 1 | 6.33 |
| CHEMBL3613272 | — | — | 1 | 6.24 |
| CHEMBL3260398 | — | — | 1 | 6.21 |
| CHEMBL1801958 | — | — | 1 | 6.10 |
| CHEMBL3613276 | — | — | 1 | 6.03 |
| CHEMBL3613068 | — | — | 1 | 5.86 |
| CHEMBL1801963 | — | — | 1 | 5.67 |
| CHEMBL3613275 | — | — | 1 | 5.59 |
| CHEMBL1599895 | — | — | 1 | 5.55 |
| CHEMBL3613269 | — | — | 1 | 5.47 |
| CHEMBL3613270 | — | — | 1 | 5.31 |
| CHEMBL1328072 | — | — | 1 | 5.28 |
| CHEMBL3613274 | — | — | 1 | 5.23 |
| CHEMBL3613268 | — | — | 1 | 5.22 |
| CHEMBL3613264 | — | — | 1 | 5.08 |
| CHEMBL138314 | 4,4'-DIMETHOXYCHALCONE | — | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1339821 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL595846 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3613158 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2013137 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL1802004 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL423911 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL3613273 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL1801962 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL3613271 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL2236844 | — | IC50 | = | 419.0 | nM | 6.38 |
| CHEMBL34398 | 4'-METHOXYCHALCONE | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL3613272 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3260398 | — | IC50 | = | 624.0 | nM | 6.21 |
| CHEMBL1801958 | — | IC50 | = | 793.0 | nM | 6.10 |
| CHEMBL3613276 | — | IC50 | = | 937.0 | nM | 6.03 |
| CHEMBL3613068 | — | IC50 | = | 1396.0 | nM | 5.86 |
| CHEMBL1801963 | — | IC50 | = | 2118.0 | nM | 5.67 |
| CHEMBL3613275 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL1599895 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL3613269 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL3613270 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL1328072 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL3613274 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL3613268 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL3613264 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL138314 | 4,4'-DIMETHOXYCHALCONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL8706 | CLORGILINE | IC50 | > | 1000.0 | nM | - |
| CHEMBL3613265 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL585432 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3613266 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3613267 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL287154 | — | IC50 | > | 10000.0 | nM | - |