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Assay Detail

CHEMBL3614711

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of DAAO (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D-amino-acid oxidase (CHEMBL5485)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase Inhibitors.
Hin N, Duvall B, Ferraris D, Alt J, Thomas AG, Rais R, Rojas C, Wu Y, Wozniak KM, Slusher BS, Tsukamoto T.
J Med Chem (2015) 58 : 7258 -7272
PubMed 26309148 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.26 5.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3613913 1 5.51
CHEMBL161 CEFTRIAXONE 4.0 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3613913 IC50 = 3100.0 nM 5.51
CHEMBL161 CEFTRIAXONE IC50 = 10000.0 nM 5.00